Confidently Backed by the Extensive
Experimental and AI Expertise of Two Industry
Leaders: Charles River + Valo Health
Logica® is a transformative solution that redefines your drug discovery journey. We’re not just an artificial intelligence AI-enabled point solution or add-on; we’re your partner in crafting small molecule solutions tailored to your specifications.
Our integrated, AI-driven process sets us apart from traditional outsourcing, ensuring outcomes that we align collaboratively to your drug discovery objectives. Explore our two powerful solutions that are redefining the state of the art in AI drug discovery solutions: Logica-AL (Advanceable Lead) and Logica-C (Candidate).
Logica Process Stack
Fully Integrated and Computationally Enabled
Logica Process Stack
Fully Integrated and Computationally Enabled
Logica-AL: Where Precision Meets Promise
Your journey to better leads begins with Logica-AL.
Our expertise-driven approach to delivering advanceable leads
includes a comprehensive range of drug discovery services:
Predictive Models for Precision
- Leverage >30 billion compound virtual library, >1 million member high-throughput screening (HTS), and >7 billion member DNA-encoded library (DEL) data
- Harness expert knowledge and data science to create predictive models that guide decision making
Deploy Models to Custom Chemical Spaces
- Deploy predictive models to explore even larger bespoke chemical spaces designed to deliver leads against your lead success criteria
- Iteratively employ rapid array chemistry, target assays, selectivity assays, and early ADME profiles to characterize and expand highest value series
Logica-C: Charting Your Course to Success
Once you have your advanceable leads from Logica-AL, you can choose our Logica-C offering to move you forward to preclinical development.
Continuing With Confidence
- Continue to optimize a suite of predictive models alongside your leads to efficiently converge on candidates
- Integrate models to drive medicinal chemistry for target engagement, PK/PD, pharmacology, in vitro safety, and scale-up goals
- Prepare your candidate for formal GLP toxicology evaluation and IND-enabling studies
Building on a Legacy of Success
With over 50 integrated drug discovery projects recently completed through Charles River, our expertise spans numerous therapeutic areas and target classes.
Therapeutic Areas
CNS
Oncology
Fibrosis
Respiratory
Anti-infective
And others
Target Classes
Kinases
Phenotypic targets
Ion channels
Proteases
Enzymes
RNA targets
Transcription factors
Membrane receptors
GPCRs
And others
Accelerate and Ensure Your Drug Discovery Journey With Logica’s Distinctive Promises
To help ensure your success, we aim to deliver on three key outcomes: Certainty, Quality, Advanceability
CERTAINTY
Receive at least one advanceable lead series supporting your accelerated path to a candidate
QUALITY
Each series is rigorously assessed for its potential to advance to the candidate stage
ADVANCEABILITY
Drive potency, selectivity, and early ADME profiles for rapid advancement
CERTAINTY
Leverage insights from Logica-AL for increased success
QUALITY
Obtain a candidate ready for GLP tox programs and IND-enabling studies
ADVANCEABILITY
Possess a candidate with efficacy, safety, and projected human dose profiles for preclinical development